Arbeitsgruppe Horn

 

Dr. Susanne Horn
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Telefon: +49 (0)341 97 22 152
Telefax: +49 (0)341 97 22 159

 

Arbeitsgruppe Horn

 

Dr. Susanne Horn
E-Mail: Diese E-Mail-Adresse ist vor Spambots geschützt! Zur Anzeige muss JavaScript eingeschaltet sein!

Telefon: +49 (0)341 97 22 152
Telefax: +49 (0)341 97 22 159

 

Overview

In our young team of computational scientists we perform translational, connective work on complex molecular genetic data sets with a focus on cancer. We improve analyses of large-scale genetic data and associated clinical and phenotypic traits bridging across medical fields, such as oncoloy, dermatology and obesity research. We are based at the Medical Faculty of the University of Leipzig and the Department of Dermatology and the German Cancer Consortium (DKTK) at the University Hospital Essen, Germany. 
   

Research

You'll find detailed information about projects under the following link: www.hornlab.org

Team

  • Dr. Susanne Horn (Group Leader)
  • Myriam Boeschen (MSc student)
  • Udo Stenzel (programmer)
  • Christina Kuhn
  • Sven-Holger Puppel

Publications

Peer-reviewed Publications

  1. Lina Such, Fang Zhao, Derek Liu, Beatrice Thier, Vu Thuy Khanh Le-Trilling, Antje Sucker, Christoph Coch, Natalia Pieper, Sebastian Howe, Hilal Bhat, Halime Kalkavan, Cathrin Ritter, Robin Brinkhaus, Selma Ugurel, Johannes Köster, Ulrike Seifert, Ulf Dittmer, Martin Schuler, Karl S. Lang, Thomas A. Kufer, Gunther Hartmann, Jürgen C. Becker, Susanne Horn, Soldano Ferrone, David Liu, Eliezer M. Van Allen, Dirk Schadendorf, Klaus Griewank, Mirko Trilling, Annette Paschen. Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy. Clin Invest. 2020;130(8):4266-4281.

  2. E. Livingstone, A. Zaremba , S. Horn , S. Ugurel , B. Casalini , M. Schlaak , J.C. Hassel , R. Herbst , J.S. Utikal , B. Weide , R. Gutzmer , F. Meier , C. Koelsche , E. Hadaschik , A. Sucker , H. Reis , S. Merkelbach‐Bruse , M. Siewert , F. Sahm , A. von Deimling , I. Cosgarea , L. Zimmer , D. Schadendorf , B. Schilling , K.G. Griewank. GNAQ and GNA11 mutant nonuveal melanoma: a subtype distinct from both cutaneous and uveal melanoma. British Journal of Dermatology. 2020; https://doi.org/10.1111/bjd.18947.
  3. Susanne Horn, Margaret Au, Lina Basel-Salmon, Pinar Bayrak-Toydemir, Alexander Chapin, Lior Cohen, Mariet W Elting, John M Graham Jr, Claudia Gonzaga-Jauregui, Osnat Konen, Max Holzer, Johannes Lemke, Christine E Miller, Linda K Rey, Nicole I Wolf, Marjan M Weiss, Quinten Waisfisz, Ghayda M Mirzaa, Dagmar Wieczorek, Heinrich Sticht, Rami Abou Jamra. De novo variants in PAK1 lead to intellectual disability with macrocephaly and seizures. Brain. 2019; 142(11):3351-3359.

  4. Susanne Horn, Adina Figl, P Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar. TERT promoter mutations in familial and sporadic melanoma. Science. 2013;