(# correspondence; * First Author; 1 Maiden name) 



 (# correspondence; * First Author; 1 Maiden name) 





  • Buniatian GH, Weiskirchen R, Weiss TS, Schwinghammer U, Fritz M, Seferyan T, Proksch B, Glaser M, Lourhmati A, Buadze M, Borkham-Kamphorst E, Gaunitz F, Gleiter CH, Lang T, Schaeffeler E, Tremmel R, Cynis H, Frey WH 2nd, Gebhardt R, Friedman SL, Mikulits W, Schwab M, Danielyan L. Antifibrotic Effects of Amyloid-Beta and Its Loss in Cirrhotic Liver. Cells 2020; 9: 452.
  • Busche M, Tomilova O, Schütte J, Werner S, Beer M, Groll N, Hagmeyer B, Pawlak M, Jones PD, Schmees C, Becker H, Schnabel J, Gall K, Hemmler R, Matz-Soja M, Damm G, Beuck S, Klaassen T, Moer J, Ullrich A, Runge D, Schenke-Layland K, Gebhardt R, Stelzle M. HepaChip-MP - a twenty-four chamber microplate for a continuously perfused liver coculture model. Lab Chip 2020; 20: 2911-2926. 
  • Cokan KB, Urlep, Lorbek G, Matz-Soja M, Skubic C, Perse M, Jeruc J, Juvan P, Rezen T, Rozman D. Chronic Disruption of the Late Cholesterol Synthesis Leads to Female-Prevalent Liver Cancer. Cancers (Basel) 2020; 12: 3302. 
  • Dannhäuser S, Lux TJ, Hu C, Selcho M, Chen JT, Ehmann N, Sachidanandan D, Stopp S, Pauls D, Pawlak M, Langenhan T, Soba P, Rittner HL, Kittel RJ. Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. Elife 2020; 9: 56738-56738.
  • Enigk K, Jentsch H, Rodloff AC, Eschrich K, Stingu CS. Activity of five antimicrobial peptides against periodontal as well as non-periodontal pathogenic strains. J Oral Microbiol 2020; 12: 1829405.
  • Langenhan T. Adhesion G protein-coupled receptors-Candidate metabotropic mechanosensors and novel drug targets.
    Basic Clin Pharmacol Toxicol 2020; 126 Suppl 6: 5-16.
  • Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA. G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. Nat Chem Biol 2020; 16: 1343-1350.
  • Spormann L, Rennert C, Kolbe E, Ott F, Lossius C, Lehmann R, Gebhardt R, Berg T, Matz-Soja M. Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver. Cells 2020; 9(8): 1817.



  • Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors. Br J Pharmacol. 2019; 176 Suppl 1:S21-S141.
  • Blanco-Redondo B, Nuwal N, Kneitz S, Nuwal T, Halder P, Liu Y, Ehmann N, Scholz N, Mayer A, Kleber J, Kähne T, Schmitt D, Sadanandappa MK, Funk N, Albertova V, Helfrich-Förster C, Ramaswami M, Hasan G, Kittel RJ, Langenhan T, Gerber B, Buchner E. Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing, and behavioural plasticity in adult Drosophila. J Exp Biol. 2019. pii: jeb.203505. doi: 10.1242/jeb.203505. [Epub ahead of print].
  • Kessler R, Fleischer M, Springsguth C, Bigl M, Warnke JP, Eschrich K. Prognostic Value of PFKFB3 to PFKFB4 mRNA Ratio in Patients With Primary Glioblastoma (IDH-Wildtype). J Neuropathol Exp Neurol. 2019; 78: 865-870.
  • Langenhan T. Adhesion G protein-coupled receptors - candidate metabotropic mechanosensors and novel drug targets. Basic Clin Pharmacol Toxicol. 2019. doi: 10.1111/bcpt.13223. [Epub ahead of print]
  • Marbach-Breitrück E, Matz-Soja M, Abraham U, Schmidt-Heck W, Sales S, Rennert C, Kern M, Aleithe S, Spormann L, Thiel C, Gerlini R, Arnold K, Klöting N, Guthke R, Rozman D, Teperino R, Shevchenko A, Kramer A, Gebhardt R. Tick-tock hedgehog-mutual crosstalk with liver circadian clock promotes liver steatosis. J Hepatol. 2019; 70: 1192-1202.
  • Matz-Soja M. Hedgehog Signaling and Liver Lipid Metabolism. In: Patel VB: The molecular nutrition of fats. Academic Press, an imprint of Elsevier, London, San Diego, Cambridge, Oxford. 2019: 201–212.
  • Min Q, Molina L, Li J, Adebayo Michael AO, Russell JO, Preziosi ME, Singh S, Poddar M, Matz-Soja M, Ranganathan S, Bell AW, Gebhardt R, Gaunitz F, Yu J, Tao J, Monga SP. β-Catenin and Yes-Associated Protein 1 Cooperate in Hepatoblastoma Pathogenesis. Am J Pathol. 2019; 189: 1091-1104.
  • Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S,Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences. 2019; 1456: 5-25.
  • Scholz N, Langenhan T, Schöneberg T. Revisiting the classification of adhesion GPCRs. Ann N Y Acad Sci. 2019; 1456: 80-95.
  • Scholz N, Ehmann N, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Meyer J, Lamberty M, Altrichter S, Bormann A, Hallermann S, Pauli M, Heckmann M, Stigloher C, Langenhan T, Kittel RJ. Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix. J Cell Biol. 2019; 218: 1011-1026. 
  • Wieduwild R, Xu Y, Ostrovidov S, Khademhosseini A, Zhang Y, Orive G. Engineering Hydrogels beyond a Hydrated Network. Adv Healthc Mater. 2019; 8(14).


  • Blanco-Redondo B, Langenhan T. Parallel Genomic Engineering of Two Drosophila Genes Using Orthogonal attB/attP Sites. G3 (Bethesda). 2018; 8: 3109-3118.
  • Brosch M, Kattler K, Herrmann A, von Schönfels W, Nordström K, Seehofer D, Damm G, Becker T, Zeissig S, Nehring S, Reichel F, Moser V, Thangapandi RV, Stickel F, Baretton G, Röcken C, Muders M, Matz-Soja M, Krawczak M, Gasparoni G, Hartmann H, Dahl A, Schafmayer C, Walter J, Hampe J. Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control. Nat Commun. 2018; 9: 4150.
  • Cohen H, Barash H, Meivar-Levy I, Molakandov K, Ben-Shimon M, Gurevich M, Zoabi F, Har-Zahav A, Gebhardt R, Gaunitz F, Gurevich M, Mor E, Ravassard P, Greenberger S, Ferber S. The Wnt/ß-catenin pathway determines the predisposition and efficiency of liver-to -pancreas reprogramming. Hepatology. 2018; 68: 1589-1603.
  • Dall M, Penke M, Sulek K, Matz-Soja M, Holst B, Garten A, Kiess W, Treebak JT. Hepatic NAD+ levels and NAMPT abundance are unaffected during prolonged high-fat diet consumption in C57BL/6JBomTac mice. Mol Cell Endocrinol. 2018; 473: 245-256.
  • Pieroh P, Wagner DC, Alessandri B, Dabbagh Nazari M, Ehrlich A, Ghadban C, Hobusch C, Birkenmeier G, Dehghani F. Comparativ Examination of Temporal Glyoxalase 1 Variations Following Perforant Pathway Transection, Excitotoxicity, and Controlled Cortical Impact Injury. Neurotox Res. 2018; 33: 412-421.
  • Rennert C, Vlaic S, Marbach-Breitruck E, Thiel C, Sales S, Shevchenko A, Gebhardt R, Matz-Soja M. The Diurnal Timing of Starvation Differently Impacts Murine Hepatic Gene Expression and Lipid Metabolism - A Systems Biology Analysis Using Self-Organizing Maps. Front Physiol. 2018; 9: 1180.
  • Schaumann R, Dallacker-Losensky K, Rosenkranz C, Genzel GH, Stingu CS, Schellenberger W, Schulz-Stubner S, Rodloff AC, Eschrich K. Discrimination of Human Pathogen Clostridium Species Especially of the Heterogeneous C. sporogenes and C. botulinum by MALDI-TOF Mass Spectrometry. Curr Microbiol. 2018; 75: 1506-1515.
  • Scholz N. Cancer Cell Mechanics: Adhesion G Protein-coupled Receptors in Action? Front Oncol. 2018; 8: 59. 


  • Altrichter S, Haase M, Loh B, Kuhn A, Leptihn S. Mechanism of the Spontaneous and Directional Membrane Insertion of a 2-Transmembrane Ion Channel. ACS Chem Biol. 2017; 12: 380-388.
  • Alwahsh SM, Gebhardt R. Dietary fructose as a risk f actor for non-alcoholic fatty liver disease (NAFLD). Arch Toxicol. 2017; 91: 1545-1563.
  • Braune J, Weyer U, Matz-Soja M, Hobusch C, Kern M, Kunath A, Kloting N, Kralisch S, Bluher M, Gebhardt R, Zavros Y, Bechmann I, Gericke M. Hedgehog signalling in myeloid cells impacts on body weight, adipose tissue inflammation and glucose metabolism. Diabetologia. 2017; 60: 889-899.
  • Debebe T, Biagi E, Soverini M, Holtze S, Hildebrandt TB, Birkemeyer C, Wyohannis D, Lemma A, Brigidi P, Savkovic V, Konig B, Candela M, Birkenmeier G. Unraveling the gut microbiome of the long-lived nak ed mole-rat. Sci Rep. 2017; 7: 9590.
  • Kolb M, Kurz S, Schafer A, Huse K, Dietz A, Wichmann G, Birkenmeier G. Verification and characterization of an alternative low density lipoprotein receptor-related protein 1 splice variant. PLoS One. 2017; 12(6): e0180354.
  • Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, Volke D, Dehghani F, Buzdin A, Engel K, Robitzki A, Hoffmann R, Gockel I, Birkenmeier G. The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat. PLoS One. 2017; 12(12): e0189514.
  • Matz-Soja M. Computational modelling of Hedgehog signalling in liver Regeneration. Drug Discov Today: Disease Models 2017; 22: 45-50.
  • Penke M, Schuster S, Gorski T, Gebhardt R, Kiess W, Garten A. Oleate ameliorates palmitate-induced reduction of NAMPT activity and NAD levels in primary human hepatocytes and hepatocarcinoma cells. Lipids Health Dis. 2017; 16: 191.
  • Pieroh P, Wagner DC, Ghadban C, Birkenmeier G, Dehghani F. Ethyl pyruvate does not require microglia for mediating neurop rotection after excitotoxic injury. CNS Neurosci Ther. 2017; 23: 798-807.
  • Rennert C, Eplinius F, Hofmann U, Johanning J, Rolfs F, Schmidt-Heck W, Guthke R, Gebhardt R, Ricken AM, Matz-Soja M. Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility. Arch Toxicol. 2017; 91(11): 3677-3687.
  • Scholz N, Guan C, Nieberler M, Grotemeyer A, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Promel S, Nagel G, Langenhan T, Kittel RJ. Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. Elife. 2017; 6: 28360.
  • Stingu CS, Eschrich K, Thiel J, Borgmann T, Schaumann R, Rodloff AC. Identification of viridans streptococci With Matrix-Assisted Laser Desorption & Ionization Time-of-flight Mass Spectrometry by an In-house Method and a Commercially Available System. Ann Lab Med. 2017; 37: 434-437.
  • Urlep Z, Lorbek G, Perse M, Jeruc J, Juvan P, Matz-Soja M, Gebhardt R, Bjorkhem I, Hall JA, Bonneau R, Littman DR, Rozman D. Disrupting Hepatocyte Cyp51 from Cholesterol Synthesis Leads to Progressive Liver Injury in the Developing Mouse and Decreases RORC Signalling. Sci Rep. 2017; 7: 40775.
  • Weigand K, Tischler-David U, Gebhardt R, Steisslinger HW, Matz-Soja M, Schmidt KH. Feedback Inhibition of apolipoprotein A-I Synthesis by ist propeptide in hepatocyte cell culture and in the
    cell-free System. Journal of Hepatology and Gastroenterology. 2017; 2: 12-17.
  • Wewering F, Jouy F, Wissenbach DK, Gebauer S, Bluher M, Gebhardt R, Pirow R, von Bergen M, Kalkhof S, Luch A, Zellmer S. Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system. Arch Toxicol. 2017; 91: 799-810. 


  • Backhaus P, Langenhan T, Neuser K. Effects of transgenic expression of botulinum toxins in Drosophila. Journal of Neurogenetics. 2016; 30: 22-31.
  • Birkenmeier G, Hemdan NY, Kurz S, Bigl M, Pieroh P, Debebe T, Buchold M, Thieme R, Wichmann G, Dehghani F. Ethyl Pyruvate Combats Human Leukemia Cells but Spares Normal Blood Cells.
    PLoS One. 2016; 11(8): e0161571.
  • Debebe T, Holtze S, Morhart M, Hildebrandt TB, Rodewald S, Huse K, Platzer M, Wyohannes D, Yirga S, Lemma A, Thieme R, Konig B, Birkenmeier G. Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat. Gut Pathog. 2016; 8: 25.
  • Debebe T, Kruger M, Huse K, Kacza J, Muhlberg K, Konig B, Birkenmeier G. Ethyl Pyruvate: An Anti-Microbial Agent that Selectively Targets Pathobionts and Biofilms. PLoS One 2016; 11(9): e0162919-9.
  • Ghallab A, Celliere G, Henkel SG, Driesch D, Hoehme S, Hofmann U, Zellmer S, Godoy P, Sachinidis A, Blaszkewicz M, Reif R, Marchan R, Kuepfer L, Haussinger D, Drasdo D, Gebhardt R, Hengstler JG. Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases. J Hepatol. 2016; 64: 860-871.
  • Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG. Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue. Arch Toxicol. 2016; 90: 2513-29.
  • Hutschenreuther A, Bigl M, Hemdan NY, Debebe T, Gaunitz F, Birkenmeier G. Modulation of GLO1 Expression Affects Malignant Properties of Cells. Int J Mol Sci. 2016; 17(12): E2133.
  • Langenhan T#, Piao X#, Monk KR#. Adhesion G protein-coupled receptors in nervous system development and disease. Nature Reviews Neuroscience. 2016; 17: 550-61.
  • Marcos R, Lopes C, Malhao F, Correia-Gomes C, Fonseca S, Lima M, Gebhardt R, Rocha E. Stereological assessment of sexual dimorphism in the rat liver reveals differences in hepatocytes and Kupffer cells but not hepatic stellate cells. J Anat. 2016; 228: 996-1005.
  • Matz-Soja M, Rennert C, Schönefeld K, Aleithe S, Boettger J, Schmidt-Heck W, Weiss TS, Hovhannisyan A, Zellmer S, Klöting N, Schulz A, Kratzsch J, Guthke R, Gebhardt R. Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis. Elife. 2016; 5. pii: e13308. doi: 10.7554/eLife.13308.
  • Nieberler M, Kittel RJ, Petrenko AG, Lin HH, Langenhan T. Control of Adhesion GPCR Function Through Proteolytic Processing. In: Langenhahn T, Schoneberg T: Handbook of experimental pharmacology. Springer Verlag, Berlin (2016); 83-109.
  • Scholz N, Monk KR, Kittel RJ, Langenhan T. Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors. In: Langenhahn T, Schoneberg T: Handbook of experimental pharmacology.
    Springer Verlag, Berlin (2016); 221-247.



  • Beck K, Ehmann N, Andlauer TF, Ljaschenko D, Strecker K, Fischer M, Kittel RJ, Raabe T. Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons. Dis Model Mech. 2015; 8: 1389-400.
  • Böttger J, Arnold K, Thiel C, Rennert C, Aleithe S, Hofmann U, Vlaic S, Sales S, Shevchenko A, Matz-Soja M. RNAi in murine hepatocytes: the agony of choice-a study of the influence of lipid-based transfection reagents on hepatocyte metabolism. Arch Toxicol. 2015; 89:1579-88.
  • Hamann J†,#, Aust G†, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T†, Schiöth HB†,#. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors. Pharmacological Reviews. 2015; 67: 338-67.
  • Langenhan T#, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR#. Model organisms in GPCR research. Molecular Pharmacology. 2015; 88: 596-603.
  • Monk K, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, Liebscher I. Adhesion GPCRs: From in vitro pharmacology to in vivo mechanisms. Mol. Pharma. 2015; 88: 617-23.
  • Schmidt-Heck W*, Matz-Soja M*, Aleithe S*, Marbach E, Guthke R, Gebhardt R. Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes. Mol Biosyst. 2015; 11: 2190-7. * Contributed equally to this manuscript.
  • Scholz N†, Gehring J†, Guan C†, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ#, Langenhan T#. The Adhesion GPCR Latrophilin/CIRL shapes mechanosensation. Cell Reports. 2015; 11: 866-74.


  • Dawydow A†, Gueta R†, Ljaschenko D, Ullrich S, Hermann M, Ehmann N, Gao S, Fiala A, Langenhan T, Nagel G#, Kittel RJ#. Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications. Proceedings of the National Academy of Sciences of the USA. 2014; 111:13972-7.
  • Ehmann N, van de Linde S, Alon A, Ljaschenko D, Keung XZ, Holm T, Rings A, DiAntonio A, Hallermann S, Ashery U, Heckmann M, Sauer M, Kittel RJ. Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nat Commun. 2014; 5: 4650.
  • Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin, H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors. Annals of the New York Academy of Sciences. 2014; 1333: 43-64.
  • Matz-Soja M, Aleithe S, Marbach E, Böttger J, Arnold K, Schmidt-Heck W, Kratzsch J, Gebhardt R. Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal. 2014; 12 :11.
  • Stock P, Ljaschenko D, Heckmann M, Dudel J. Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J Physiol. 2014; 592: 2501-17.


  • Ljaschenko D, Ehmann N, Kittel RJ. Hebbian plasticity guides maturation of glutamate receptor fields in vivo. Cell Rep. 2013; 3: 1407-13.
  • Langenhan T†,#, Aust G†, Hamann J†. Sticky signaling – Adhesion class G protein-coupled receptors take the stage. Science Signaling. 2013; 6: re3. (Access through
  • Prömel S, Aust G, Langenhan T, Schöneberg T. Adhäsions-G-Protein-gekoppelte Rezeptoren — rätselhafte Riesen. Biospektrum. 2013; 19: 717-719.
  • Prömel S†, Langenhan T†,#, Araç D†,#. Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins. Trends in Pharmacological Sciences. 2013; 34: 470-78.


  • Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. Dissecting signaling and functions of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences. 2012; 1276: 1-25.
  • Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP*, Langenhan T*,#. The GPS motif is a molecular switch for bimodal activities of Adhesion-class G protein-coupled receptors. Cell Reports. 2012; 2: 321-31.
  • Prömel S#, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Grosse J, Schöneberg T, Russ AP, Langenhan T#. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCRs in mouse. Developmental Dynamics. 2012; 241: 1591-1602.


  • Langenhan T, Russ AP. Latrophilin signalling in tissue polarity and morphogenesis. Advances in Experimental Medicine and Biology. 2010; 706: 37-48. (Adhesion-GPCRs: Structure to Function, edited by Simon Yona and Martin Stacey)
  • McGuinness L, Taylor C, Taylor RDT, Yau C, Langenhan T, Hart ML, Christian H, Tynan PW, Donnelly P, Emptage NJ. Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency. Neuron. 2010; 68: 1109–27.
  • Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Davies B, Aparicio SAJR, Grosse J, Russ AP. The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010; 5: e14047.


  • Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP. Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Developmental Cell. 2009; 17: 494-504.


  • Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID. Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Structure. 2008; 16: 944-53.