Arbeitsgruppe Scholz

 

Dr. Nicole Scholz
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Telefon: +49 (0)341 97 22 145
Telefax: +49 (0)341 97 22 109

 

Science

Life as we know it crucially depends on the faculty of cells to sense mechanical stimuli. Adhesion-type G protein-coupled receptors (adhesion-GPCR) are expressed in most of not all organ systems and have been found to shape different physiological processes mechano-dependently. However, the underlying mechanisms of adhesion-GPCR function remain largely mysterious. We study the molecular mechanisms that shape adhesion-GPCR-dependent perception, -transduction and -response. Here, we strive to understand how these aspects intersect with mechanobiological phenomena, particularly in neuronal tissues, and which molecules adhesion-GPCR ‘talk’ to in order to enable neuronal physiology. Building on our understanding of adhesion-GPCR function in physiological settings we are also aiming to understand how adhesion-GPCR contribute to set up the mechanical signature of cells and tissues in the context of cancer, cerebral edema and brain metabolism. Further, we are investigating synaptic components involved in synaptic vesicle tethering at the presynaptic active zone, a process vital for sustained neuronal activity. To these ends, we take advantage of Drosophila melanogaster`s unprecedented genetic amenability and accessibility for imaging, functional and behavioral approaches.

 

 

Team

  • Anne Bormann (PhD Candidate)
  • Anne-Kristin Dahse (PhD Candidate)
  • Lucia Ernst (MD Candidate)
  • Marek Körner (PhD Candidate; jointly with LeDuc Lab)
  • Hauke Staake (MD Candidate)

Alumni:

  • Carlo Eberlein (B.Sc. Student 2020; jointly with Langenhan lab)
  • Johanna Irmer (M.Sc. Student 2018; jointly with Langenhan lab)
  • Joris Lehmann (M.Sc. Student 2020; jointly with Ljaschenko lab)
  • Anna-Luka Ober (M.Sc. Student 2020)

 

Funding

 

 

Publications

(# correspondence; * First Author; 1 Maiden name)

  • Heydasch U, Kessler R, Warnke JP, Eschrich K, Scholz N#, Bigl M#. Functional diversity of PFKFB3 splice variants in glioblastomas. PLoS One. 2021; 16:e0241092. doi: 10.1371/journal.pone.0241092. eCollection 2021.

  • Smolič T, Tavčar P, Horvat A, Černe U, Vasle AH, Tratnjek L, Kreft ME, Scholz N, Matis M, Petan T, Zorec R, Vardjan N. Astrocytes in stress accumulate lipid droplets. Glia. 2021. doi: 10.1002/glia.23978. Online ahead of print.
  • Beliu G*, Altrichter S*, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW#, Sauer M#, Langenhan L#.  Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain. Molecular Cell. 2021; S1097-2765(20)30963. Epub ahead of print. *These authors contributed equally
  • Blanco-Redondo B, Nuwal N, Kneitz S, Nuwal T, Halder P, Liu Y, Ehmann N, Scholz N, Mayer A, Kleber J, Kähne T, Schmitt D, Sadanandappa MK, Funk N, Albertova V, Helfrich-Förster C, Ramaswami M, Hasan G, Kittel RJ, Langenhan T, Gerber B, Buchner E. Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing, and behavioural plasticity in adult Drosophila. J Exp Biol. 2019. pii: jeb.203505. doi: 10.1242/jeb.203505. [Epub ahead of print].
  • Scholz N, Langenhan T, Schöneberg T. Revisiting the classification of adhesion GPCRs. Ann N Y Acad Sci. 2019; 1456: 80-95.
  • Morgan RK, Anderson GR, Araç D, Aust G, Balenga N, Boucard A, Bridges JP, Engel FB, Formstone CJ, Glitsch MD, Gray RS, Hall RA, Hsiao CC, Kim HY, Knierim AB, Kusuluri DK, Leon K, Liebscher I, Piao X, Prömel S, Scholz N, Srivastava S,Thor D, Tolias KF, Ushkaryov YA, Vallon M, Van Meir EG, Vanhollebeke B, Wolfrum U, Wright KM, Monk KR, Mogha A. The expanding functional roles and signaling mechanisms of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences. 2019; doi: 10.1111/nyas.14094. [Epub ahead of print].
  • Scholz N*, Ehmann N*, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Pauli M, Heckmann M, Stigloher C, Langenhan T#, Kittel RJ#. Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix. Journal of Cell Biology. 2019; 218: 1011-1026.
  • Scholz N. Cancer Cell Mechanics: Adhesion G Protein-Coupled Receptors in Action? Front. Oncol. 2018; 8:59.
  • Scholz N*, Guan C*, Nieberler M*, Grotemeyer A*, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T#, Kittel RJ#. Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. eLife. 2017; 6: e28360. See also Insight article by Wayne A Johnson. Mechanotransduction: Two views of the same stimulus.
  • Scholz N#, Monk KR, Kittel RJ, Langenhan T#. Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors.  Handb Exp Pharmacol. 2016; 234: 221-247. A chapter from Adhesion G Protein-coupled Receptors: Molecular, Physiological and Pharmacological Principles in Health and Disease (Tobias Langenhan, Torsten Schöneberg, Eds.). Chapters 1, 2 and 3 can be accessed online.
  • Scholz N*, Gehring J*, Guan C*, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ#, Langenhan T#. The Adhesion GPCR Latrophilin/CIRL shapes mechanosensation. Cell Reports. 2015; 11:866-874.
  • Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N1, Lin, H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors. Annals of the New York Academy of Sciences. 2014; 1333: 43-64.