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  • Beck K, Ehmann N, Andlauer TF, Ljaschenko D, Strecker K, Fischer M, Kittel RJ, Raabe T. Loss of the Coffin-Lowry syndrome-associated gene RSK2 alters ERK activity, synaptic function and axonal transport in Drosophila motoneurons. Dis Model Mech. 2015; 8: 1389-400.
  • Böttger J, Arnold K, Thiel C, Rennert C, Aleithe S, Hofmann U, Vlaic S, Sales S, Shevchenko A, Matz-Soja M. RNAi in murine hepatocytes: the agony of choice-a study of the influence of lipid-based transfection reagents on hepatocyte metabolism. Arch Toxicol. 2015; 89:1579-88
  • Hamann J†,#, Aust G†, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T†, Schiöth HB†,#. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors. Pharmacological Reviews. 2015; 67: 338-67.
  • Langenhan T#, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR#. Model organisms in GPCR research. Molecular Pharmacology. 2015; 88: 596-603.
  • Monk K, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, Liebscher I. Adhesion GPCRs: From in vitro pharmacology to in vivo mechanisms. Mol. Pharma. 2015; 88: 617-23.
  • Schmidt-Heck W*, Matz-Soja M*, Aleithe S*, Marbach E, Guthke R, Gebhardt R. Fuzzy modeling reveals a dynamic self-sustaining network of the GLI transcription factors controlling important metabolic regulators in adult mouse hepatocytes. Mol Biosyst. 2015; 11: 2190-7. * Contributed equally to this manuscript.
  • Scholz N†, Gehring J†, Guan C†, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ#, Langenhan T#. The Adhesion GPCR Latrophilin/CIRL shapes mechanosensation. Cell Reports. 2015; 11: 866-74.



  • Dawydow A†, Gueta R†, Ljaschenko D, Ullrich S, Hermann M, Ehmann N, Gao S, Fiala A, Langenhan T, Nagel G#, Kittel RJ#. Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications. Proceedings of the National Academy of Sciences of the USA. 2014; 111:13972-7.
  • Ehmann N, van de Linde S, Alon A, Ljaschenko D, Keung XZ, Holm T, Rings A, DiAntonio A, Hallermann S, Ashery U, Heckmann M, Sauer M, Kittel RJ. Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nat Commun. 2014; 5: 4650.
  • Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin, H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X. New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors. Annals of the New York Academy of Sciences. 2014; 1333: 43-64.
  • Matz-Soja M, Aleithe S, Marbach E, Böttger J, Arnold K, Schmidt-Heck W, Kratzsch J, Gebhardt R. Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels. Cell Commun. Signal. 2014; 12 :11. 
  • Stock P, Ljaschenko D, Heckmann M, Dudel J. Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J Physiol. 2014; 592: 2501-17.



  • Ljaschenko D, Ehmann N, Kittel RJ. Hebbian plasticity guides maturation of glutamate receptor fields in vivo. Cell Rep. 2013; 3: 1407-13.
  • Langenhan T†,#, Aust G†, Hamann J†. Sticky signaling – Adhesion class G protein-coupled receptors take the stage. Science Signaling. 2013; 6: re3. (Access through www.adhesiongpcr.org)
  • Prömel S, Aust G, Langenhan T, Schöneberg T. Adhäsions-G-Protein-gekoppelte Rezeptoren — rätselhafte Riesen. Biospektrum. 2013; 19: 717-719.
  • Prömel S†, Langenhan T†,#, Araç D†,#. Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins. Trends in Pharmacological Sciences. 2013; 34: 470-78.


  • Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T. Dissecting signaling and functions of adhesion G protein-coupled receptors. Annals of the New York Academy of Sciences. 2012; 1276: 1-25.
  • Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP*, Langenhan T*,#. The GPS motif is a molecular switch for bimodal activities of Adhesion-class G protein-coupled receptors. Cell Reports. 2012; 2: 321-31.
  • Prömel S#, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Grosse J, Schöneberg T, Russ AP, Langenhan T#. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCRs in mouse. Developmental Dynamics. 2012; 241: 1591-1602.



  • Langenhan T, Russ AP. Latrophilin signalling in tissue polarity and morphogenesis. Advances in Experimental Medicine and Biology. 2010; 706: 37-48. (Adhesion-GPCRs: Structure to Function, edited by Simon Yona and Martin Stacey)
  • McGuinness L, Taylor C, Taylor RDT, Yau C, Langenhan T, Hart ML, Christian H, Tynan PW, Donnelly P, Emptage NJ. Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency. Neuron. 2010; 68: 1109–27.
  • Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Davies B, Aparicio SAJR, Grosse J, Russ AP. The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse. PLoS One. 2010; 5: e14047.



  • Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP. Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Developmental Cell. 2009; 17: 494-504.



  • Vakonakis I, Langenhan T, Prömel S, Russ A, Campbell ID. Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Structure. 2008; 16: 944-53.
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